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Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.

ABSTRACT: A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant beta-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.

SUBMITTER: Dubois V 

PROVIDER: S-EPMC2565901 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.

Dubois Véronique V   Poirel Laurent L   Demarthe François F   Arpin Corinne C   Coulange Laure L   Minarini Luciene A R LA   Bezian Marie-Christine MC   Nordmann Patrice P   Quentin Claudine C  

Antimicrobial agents and chemotherapy 20080728 10

A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant beta-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes. ...[more]

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