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SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae.

ABSTRACT: A clinical strain of Klebsiella pneumoniae carried the bla(SHV-49) gene, encoding a novel inhibitor-resistant beta-lactamase of pI 7.6, derived from SHV-1 by the single substitution M69I. It also harbored a gene differing from bla(SHV-11) by four silent mutations and coding for a penicillinase. Both genes were chromosome located and might represent either a species-specific gene or an acquired resistance gene.

SUBMITTER: Dubois V

PROVIDER: S-EPMC525401 | biostudies-literature | 2004 Nov

REPOSITORIES: biostudies-literature

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SHV-49, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Klebsiella pneumoniae.

Dubois Véronique V Poirel Laurent L Arpin Corinne C Coulange Laure L Bebear Cécile C Nordmann Patrice P Quentin Claudine C

Antimicrobial agents and chemotherapy 20041101 11

A clinical strain of Klebsiella pneumoniae carried the bla(SHV-49) gene, encoding a novel inhibitor-resistant beta-lactamase of pI 7.6, derived from SHV-1 by the single substitution M69I. It also harbored a gene differing from bla(SHV-11) by four silent mutations and coding for a penicillinase. Both genes were chromosome located and might represent either a species-specific gene or an acquired resistance gene. ...[more]

PMID: 15504885

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