An alpha-helical peptidomimetic inhibitor of the HIV-1 Rev-RRE interaction.
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ABSTRACT:
SUBMITTER: Mills NL
PROVIDER: S-EPMC2566309 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Publications
An alpha-helical peptidomimetic inhibitor of the HIV-1 Rev-RRE interaction.
Mills Nicholas L NL Daugherty Matthew D MD Frankel Alan D AD Guy R Kiplin RK
Journal of the American Chemical Society 20060301 11
The interaction between the HIV-1 Rev protein and the Rev-Responsive Element (RRE) RNA is an attractive target for anti-viral therapy. We have designed alpha-helical peptidomimetics of Rev-like peptides using side chain-side chain macrolactam formation between positions i and i+4. One peptidomimetic having an appropriate location, orientation, and length of the macrolactam exhibited both significant helical character and specific RRE binding. This molecule displays 2-fold greater RNA specificity ...[more]
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