Ontology highlight
ABSTRACT:
SUBMITTER: Galli LM
PROVIDER: S-EPMC2566934 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Galli Lisa M LM Barnes Tiffany T Cheng Tina T Acosta Lisa L Anglade Adolph A Willert Karl K Nusse Roel R Burrus Laura W LW
Developmental dynamics : an official publication of the American Association of Anatomists 20060301 3
Secreted frizzled related proteins (Sfrps) are extracellular attenuators of Wnt signaling that play important roles in both embryogenesis and oncogenesis. Although Sfrps are generally thought to bind and sequester Wnts away from active receptor complexes, very little is known about the specificity of Sfrp family members for various Wnts. In the developing chick neural tube, sfrp-1, 2, and 3 transcripts are expressed in and adjacent to the dorsal neural tube, where Wnt-1 and Wnt-3a are expressed. ...[more]