Ontology highlight
ABSTRACT:
SUBMITTER: Zhi C
PROVIDER: S-EPMC2566945 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Zhi Chengxin C Long Zheng-Yu ZY Manikowski Andrzej A Comstock Jeanne J Xu Wei-Chu WC Brown Neal C NC Tarantino Paul M PM Holm Karsten A KA Dix Edward J EJ Wright George E GE Barnes Marjorie H MH Butler Michelle M MM Foster Kimberly A KA LaMarr William A WA Bachand Benoit B Bethell Richard R Cadilhac Caroline C Charron Sylvie S Lamothe Serge S Motorina Irina I Storer Richard R
Journal of medicinal chemistry 20060201 4
Novel Gram-positive (Gram+) antibacterial compounds consisting of a DNA polymerase IIIC (pol IIIC) inhibitor covalently connected to a topoisomerase/gyrase inhibitor are described. Specifically, 3-substituted 6-(3-ethyl-4-methylanilino)uracils (EMAUs) in which the 3-substituent is a fluoroquinolone moiety (FQ) connected by various linkers were synthesized. The resulting "AU-FQ" hybrid compounds were significantly more potent than the parent EMAU compounds as inhibitors of pol IIIC and were up to ...[more]