Ontology highlight
ABSTRACT:
SUBMITTER: Cincinelli R
PROVIDER: S-EPMC6177136 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
PloS one 20181009 10
Recent studies have shown that HDAC inhibitors act synergistically with camptothecin derivatives in combination therapies. To exploit this synergy, new hybrid molecules targeting simultaneously topoisomerase I and HDAC were designed. In particular, a selected multivalent agent containing a camptothecin and a SAHA-like template showed a broad spectrum of antiproliferative activity, with IC50 values in the nanomolar range. Preliminary in vivo results indicated a strong antitumor activity on human ...[more]