Ontology highlight
ABSTRACT:
SUBMITTER: DiMaio F
PROVIDER: S-EPMC2567142 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
DiMaio Frank F Kondrashov Dmitry A DA Bitto Eduard E Soni Ameet A Bingman Craig A CA Phillips George N GN Shavlik Jude W JW
Bioinformatics (Oxford, England) 20071012 21
<h4>Motivation</h4>One bottleneck in high-throughput protein crystallography is interpreting an electron-density map, that is, fitting a molecular model to the 3D picture crystallography produces. Previously, we developed ACMI (Automatic Crystallographic Map Interpreter), an algorithm that uses a probabilistic model to infer an accurate protein backbone layout. Here, we use a sampling method known as particle filtering to produce a set of all-atom protein models. We use the output of ACMI to gui ...[more]