Ontology highlight
ABSTRACT:
SUBMITTER: Luo X
PROVIDER: S-EPMC2567158 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Luo Xunrong X Pothoven Kathryn L KL McCarthy Derrick D DeGutes Mathew M Martin Aaron A Getts Daniel R DR Xia Guliang G He Jie J Zhang Xiaomin X Kaufman Dixon B DB Miller Stephen D SD
Proceedings of the National Academy of Sciences of the United States of America 20080916 38
A major challenge for human allogeneic islet transplantation is the development of effective methods to induce donor-specific tolerance to obviate the need for life-long immunosuppression that is toxic to the insulin-producing beta cells and detrimental to the host. We developed an efficient donor-specific tolerance therapy that utilizes infusions of ethylene carbodiimide (ECDI)-treated donor splenic antigen-presenting cells that results in indefinite survival of allogeneic islet grafts in the a ...[more]