Ontology highlight
ABSTRACT:
SUBMITTER: Singh A
PROVIDER: S-EPMC6677762 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Singh Amar A Ramachandran Sabarinathan S Graham Melanie L ML Daneshmandi Saeed S Heller David D Suarez-Pinzon Wilma Lucia WL Balamurugan Appakalai N AN Ansite Jeffrey D JD Wilhelm Joshua J JJ Yang Amy A Zhang Ying Y Palani Nagendra P NP Abrahante Juan E JE Burlak Christopher C Miller Stephen D SD Luo Xunrong X Hering Bernhard J BJ
Nature communications 20190802 1
Immune tolerance to allografts has been pursued for decades as an important goal in transplantation. Administration of apoptotic donor splenocytes effectively induces antigen-specific tolerance to allografts in murine studies. Here we show that two peritransplant infusions of apoptotic donor leukocytes under short-term immunotherapy with antagonistic anti-CD40 antibody 2C10R4, rapamycin, soluble tumor necrosis factor receptor and anti-interleukin 6 receptor antibody induce long-term (≥1 year) to ...[more]