Ontology highlight
ABSTRACT:
SUBMITTER: Feklistov A
PROVIDER: S-EPMC2567451 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Feklistov Andrey A Mekler Vladimir V Jiang Qiaorong Q Westblade Lars F LF Irschik Herbert H Jansen Rolf R Mustaev Arkady A Darst Seth A SA Ebright Richard H RH
Proceedings of the National Academy of Sciences of the United States of America 20080911 39
Rifamycin antibacterial agents inhibit bacterial RNA polymerase (RNAP) by binding to a site adjacent to the RNAP active center and preventing synthesis of RNA products >2-3 nt in length. Recently, Artsimovitch et al. [(2005) Cell 122:351-363] proposed that rifamycins function by allosteric modulation of binding of Mg(2+) to the RNAP active center and presented three lines of biochemical evidence consistent with this proposal. Here, we show that rifamycins do not affect the affinity of binding of ...[more]