Ontology highlight
ABSTRACT:
SUBMITTER: Hamidi T
PROVIDER: S-EPMC6102145 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Hamidi Tewfik T Singh Anup Kumar AK Veland Nicolas N Vemulapalli Vidyasiri V Chen Jianji J Hardikar Swanand S Bao Jianqiang J Fry Christopher J CJ Yang Vicky V Lee Kimberly A KA Guo Ailan A Arrowsmith Cheryl H CH Bedford Mark T MT Chen Taiping T
The Journal of biological chemistry 20180629 33
Set7/9 (also known as Set7, Set9, Setd7, and Kmt7) is a lysine methyltransferase that catalyzes the methylation of multiple substrates, including histone H3 and non-histone proteins. Although not essential for normal development and physiology, Set7/9-mediated methylation events play important roles in regulating cellular pathways involved in various human diseases, making Set7/9 a promising therapeutic target. Multiple Set7/9 inhibitors have been developed, which exhibit varying degrees of pote ...[more]