Ontology highlight
ABSTRACT:
SUBMITTER: Hills RD
PROVIDER: S-EPMC2567933 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Hills Ronald D RD Brooks Charles L CL
Biophysical journal 20080815 9
The relationship between the folding landscape and function of evolved proteins is explored by comparison of the folding mechanisms for members of the flavodoxin fold. CheY, Spo0F, and NtrC have unrelated functions and low sequence homology but share an identical topology. Recent coarse-grained simulations show that their folding landscapes are uniquely tuned to properly suit their respective biological functions. Enhanced packing in Spo0F and its limited conformational dynamics compared to CheY ...[more]