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ABSTRACT:
SUBMITTER: Makarov DE
PROVIDER: S-EPMC122558 | biostudies-literature | 2002 Mar
REPOSITORIES: biostudies-literature
Makarov Dmitrii E DE Keller Craig A CA Plaxco Kevin W KW Metiu Horia H
Proceedings of the National Academy of Sciences of the United States of America 20020301 6
Experiments have shown that the folding rate constants of two dozen structurally unrelated, small, single-domain proteins can be expressed in terms of one quantity (the contact order) that depends exclusively on the topology of the folded state. Such dependence is unique in chemical kinetics. Here we investigate its physical origin and derive the approximate formula ln(k) = ln(N) + a + bN, were N is the number of contacts in the folded state, and a and b are constants whose physical meaning is u ...[more]