Ontology highlight
ABSTRACT:
SUBMITTER: Maier AG
PROVIDER: S-EPMC2568870 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Maier Alexander G AG Rug Melanie M O'Neill Matthew T MT Brown Monica M Chakravorty Srabasti S Szestak Tadge T Chesson Joanne J Wu Yang Y Hughes Katie K Coppel Ross L RL Newbold Chris C Beeson James G JG Craig Alister A Crabb Brendan S BS Cowman Alan F AF
Cell 20080701 1
A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host red cells. These changes are caused by parasite proteins exported to the erythrocyte using novel trafficking machinery assembled in the host cell. To understand these unique modifications, we used a large-scale gene knockout strategy combined with functional screens to identify proteins exported into parasite-infecte ...[more]