Ontology highlight
ABSTRACT:
SUBMITTER: Yu M
PROVIDER: S-EPMC2569866 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20061201 48
The Gcn5-related N-acetyltransferases (GNAT) comprise one of the largest enzyme superfamilies, with over 10 000 known members represented in all kingdoms of life. ChloroacetylCoenzymeA was prepared and demonstrated to be a substrate for several GNAT members. ChloroacetylCoA (ClAcCoA) is used by the Hat1 histone acetyltransferase to correctly acetylate histone H4 in a mixture of histone proteins. Chloroacetylation can be assessed by the subsequent reaction of the chloroacetylated product with thi ...[more]