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Kinetic resolutions of indolines by a nonenzymatic acylation catalyst.

ABSTRACT: The first method for the kinetic resolution of indolines through catalytic N-acylation is described. To improve the selectivity factor, new planar-chiral PPY-derived catalysts were synthesized, wherein the chiral environment was systematically modified. This work provides a rare example of a nonenzyme-based acylation catalyst for the kinetic resolution of amines.

SUBMITTER: Arp FO

PROVIDER: S-EPMC2569996 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature

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Kinetic resolutions of indolines by a nonenzymatic acylation catalyst.

Arp Forrest O FO Fu Gregory C GC

Journal of the American Chemical Society 20061101 44

The first method for the kinetic resolution of indolines through catalytic N-acylation is described. To improve the selectivity factor, new planar-chiral PPY-derived catalysts were synthesized, wherein the chiral environment was systematically modified. This work provides a rare example of a nonenzyme-based acylation catalyst for the kinetic resolution of amines. ...[more]

PMID: 17076493

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