Kinetic resolutions of indolines by a nonenzymatic acylation catalyst.
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ABSTRACT:
SUBMITTER: Arp FO
PROVIDER: S-EPMC2569996 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
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Kinetic resolutions of indolines by a nonenzymatic acylation catalyst.
Arp Forrest O FO Fu Gregory C GC
Journal of the American Chemical Society 20061101 44
The first method for the kinetic resolution of indolines through catalytic N-acylation is described. To improve the selectivity factor, new planar-chiral PPY-derived catalysts were synthesized, wherein the chiral environment was systematically modified. This work provides a rare example of a nonenzyme-based acylation catalyst for the kinetic resolution of amines. ...[more]
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