Ontology highlight
ABSTRACT:
SUBMITTER: Heinrichsdorff J
PROVIDER: S-EPMC2572111 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Heinrichsdorff Jan J Luedde Tom T Perdiguero Eusebio E Nebreda Angel R AR Pasparakis Manolis M
EMBO reports 20080815 10
Activation of c-Jun amino-terminal kinase (JNK) facilitates tumour necrosis factor (TNF)-induced cell death. The p38 mitogen-activated protein kinase pathway is induced by TNF stimulation, but it has not been implicated in TNF-induced cell death. Here, we show that hepatocyte-specific ablation of p38alpha in mice results in excessive activation of JNK in the liver after in vivo challenge with bacterial lipopolysaccharide (LPS). Despite increased JNK activity, p38alpha-deficient hepatocytes were ...[more]