Ontology highlight
ABSTRACT:
SUBMITTER: Lanna A
PROVIDER: S-EPMC5321575 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Lanna Alessio A Gomes Daniel C O DC Muller-Durovic Bojana B McDonnell Thomas T Escors David D Gilroy Derek W DW Lee Jun Hee JH Karin Michael M Akbar Arne N AN
Nature immunology 20170123 3
Mitogen-activated protein kinases (MAPKs) including Erk, Jnk and p38 regulate diverse cellular functions and are thought to be controlled by independent upstream activation cascades. Here we show that the sestrins bind to and coordinate simultaneous Erk, Jnk and p38 MAPK activation in T lymphocytes within a new immune-inhibitory complex (sestrin-MAPK activation complex (sMAC)). Whereas sestrin ablation resulted in broad reconstitution of immune function in stressed T cells, inhibition of individ ...[more]