Ontology highlight
ABSTRACT:
SUBMITTER: Zaidi IW
PROVIDER: S-EPMC2572122 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Zaidi Iram Waris IW Rabut Gwénaël G Poveda Ana A Scheel Hartmut H Malmström Johan J Ulrich Helle H Hofmann Kay K Pasero Philippe P Peter Matthias M Luke Brian B
EMBO reports 20080815 10
In budding yeast the cullin Rtt101 promotes replication fork progression through natural pause sites and areas of DNA damage, but its relevant subunits and molecular mechanism remain poorly understood. Here, we show that in budding yeast Mms1 and Mms22 are functional subunits of an Rtt101-based ubiquitin ligase that associates with the conjugating-enzyme Cdc34. Replication forks in mms1Delta, mms22Delta and rtt101Delta cells are sensitive to collisions with drug-induced DNA lesions, but not to t ...[more]