Ontology highlight
ABSTRACT:
SUBMITTER: Braun S
PROVIDER: S-EPMC3645473 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Braun Sigurd S Garcia Jennifer F JF Rowley Margot M Rougemaille Mathieu M Shankar Smita S Madhani Hiten D HD
Cell 20110101 1
Partitioning of chromosomes into euchromatic and heterochromatic domains requires mechanisms that specify boundaries. The S. pombe JmjC family protein Epe1 prevents the ectopic spread of heterochromatin and is itself concentrated at boundaries. Paradoxically, Epe1 is recruited to heterochromatin by HP1 silencing factors that are distributed throughout heterochromatin. We demonstrate here that the selective enrichment of Epe1 at boundaries requires its regulation by the conserved Cul4-Ddb1(Cdt)² ...[more]