Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC2572259 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Li Shitao S Wang Lingyan L Berman Michael A MA Zhang Ye Y Dorf Martin E ME
Molecular cell 20061101 4
Regulation of NF-kappaB activation is controlled by a series of kinases; however, the roles of phosphatases in regulating this pathway are poorly understood. We report a systematic RNAi screen of phosphatases that modulate NF-kappaB activity. Nineteen of 250 phosphatase genes were identified as regulators of NF-kappaB signaling in astrocytes. RNAi selectively regulates endogenous chemokine and cytokine expression. Coimmunoprecipitation identified associations of distinct protein phosphatase 2A c ...[more]