Ontology highlight
ABSTRACT:
SUBMITTER: Caldarelli A
PROVIDER: S-EPMC3865536 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Caldarelli A A Müller J P JP Paskowski-Rogacz M M Herrmann K K Bauer R R Koch S S Heninger A K AK Krastev D D Ding L L Kasper S S Fischer T T Brodhun M M Böhmer F-D FD Buchholz F F
Leukemia 20130319 12
Fms-like tyrosine kinase-3 is a commonly mutated gene in acute myeloid leukemia, with about one-third of patients carrying an internal-tandem duplication of the juxtamembrane domain in the receptor (FLT3-ITD). FLT3-ITD exhibits altered signaling quality, including aberrant activation of STAT5. To identify genes affecting FLT3-ITD-mediated STAT5 signaling, we performed an esiRNA-based RNAi screen utilizing a STAT5-driven reporter assay. Knockdowns that caused reduced FLT3-ITD-mediated STAT5 signa ...[more]