Ontology highlight
ABSTRACT:
SUBMITTER: Schwartz GJ
PROVIDER: S-EPMC2572640 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Schwartz Gary J GJ Fu Jin J Astarita Giuseppe G Li Xiaosong X Gaetani Silvana S Campolongo Patrizia P Cuomo Vincenzo V Piomelli Daniele D
Cell metabolism 20081001 4
The association between fat consumption and obesity underscores the need to identify physiological signals that control fat intake. Previous studies have shown that feeding stimulates small-intestinal mucosal cells to produce the lipid messenger oleoylethanolamide (OEA) which, when administered as a drug, decreases meal frequency by engaging peroxisome proliferator-activated receptors-alpha (PPAR-alpha). Here, we report that duodenal infusion of fat stimulates OEA mobilization in the proximal sm ...[more]