Ontology highlight
ABSTRACT:
SUBMITTER: Fushimi K
PROVIDER: S-EPMC2572934 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Fushimi Kazuo K Ray Payal P Kar Amar A Wang Lei L Sutherland Leslie C LC Wu Jane Y JY
Proceedings of the National Academy of Sciences of the United States of America 20081007 41
Similar to many genes involved in programmed cell death (PCD), the caspase 2 (casp-2) gene generates both proapoptotic and antiapoptotic isoforms by alternative splicing. Using a yeast RNA-protein interaction assay, we identified RBM5 (also known as LUCA-15) as a protein that binds to casp-2 pre-mRNA. In both transfected cells and in vitro splicing assay, RBM5 enhances the formation of proapoptotic Casp-2L. RBM5 binds to a U/C-rich sequence immediately upstream of the previously identified In100 ...[more]