Ontology highlight
ABSTRACT:
SUBMITTER: Lo WY
PROVIDER: S-EPMC2573071 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Lo Wen-yi WY Botzolakis Emmanuel J EJ Tang Xin X Macdonald Robert L RL
The Journal of biological chemistry 20080821 44
Members of the Cys-loop superfamily of ligand-gated ion channels, which mediate fast synaptic transmission in the nervous system, are assembled as heteropentamers from a large repertoire of neuronal subunits. Although several motifs in subunit N-terminal domains are known to be important for subunit assembly, increasing evidence points toward a role for C-terminal domains. Using a combination of flow cytometry, patch clamp recording, endoglycosidase H digestion, brefeldin A treatment, and analyt ...[more]