Ontology highlight
ABSTRACT:
SUBMITTER: Lee WY
PROVIDER: S-EPMC2728446 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Lee Won Yong WY Free Chris R CR Sine Steven M SM
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090301 10
The nicotinic acetylcholine receptor (AChR) transduces binding of nerve-released ACh into opening of an intrinsic ion channel, yet the intraprotein interactions behind transduction remain to be fully elucidated. Attention has focused on the region of the AChR in which the beta1-beta2 and Cys-loops from the extracellular domain project into a cavity framed by residues preceding the first transmembrane domain (pre-M1) and the linker spanning transmembrane domains M2 and M3. Previous studies identi ...[more]