Ontology highlight
ABSTRACT:
SUBMITTER: Ramiere C
PROVIDER: S-EPMC2573182 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Ramière Christophe C Scholtès Caroline C Diaz Olivier O Icard Vinca V Perrin-Cocon Laure L Trabaud Mary-Anne MA Lotteau Vincent V André Patrice P
Journal of virology 20080903 21
Hepatitis B virus (HBV) core promoter activity is positively and negatively regulated by nuclear receptors, a superfamily of ligand-activated transcription factors, via cis-acting sequences located in the viral genome. In this study, we investigated the role of farnesoid X receptor alpha (FXRalpha) in modulating transcription from the HBV core promoter. FXRalpha is a liver-enriched nuclear receptor activated by bile acids recognizing hormone response elements by forming heterodimers with retinoi ...[more]