Integration of rous sarcoma virus DNA: a CA dinucleotide is not required for integration of the U3 end of viral DNA.
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ABSTRACT:
SUBMITTER: Oh J
PROVIDER: S-EPMC2573277 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Integration of rous sarcoma virus DNA: a CA dinucleotide is not required for integration of the U3 end of viral DNA.
Oh Jangsuk J Chang Kevin W KW Hughes Stephen H SH
Journal of virology 20080903 22
The two ends of RSV linear DNA are independently inserted into host DNA by integrase in vivo. We previously showed that the range of U3 sequences that are acceptable substrates for integrase appeared to be greater than the range of acceptable U5 sequences in vivo. We have done additional experiments to determine which U3 sequences are good integrase substrates. On the U3 end, there does not appear to be a stringent requirement for the canonical CA, integrase can efficiently remove three nucleoti ...[more]
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