Ontology highlight
ABSTRACT:
SUBMITTER: Lu LY
PROVIDER: S-EPMC2573299 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Lu Lin-Yu LY Wood Jamie L JL Minter-Dykhouse Katherine K Ye Lin L Saunders Thomas L TL Yu Xiaochun X Chen Junjie J
Molecular and cellular biology 20080915 22
Polo-like kinases (Plks) are serine/threonine kinases that are highly conserved in organisms from yeasts to humans. Previous reports have shown that Plk1 is critical for all stages of mitosis and may play a role in DNA replication during S phase. While much work has focused on Plk1, little is known about the physiological function of Plk1 in vivo. To address this question, we generated Plk1 knockout mice. Plk1 homozygous null mice were embryonic lethal, and early Plk1(-/-) embryos failed to surv ...[more]