Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC2574430 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Liu Jianxi J Asuncion-Chin Maria M Liu Pengchong P Dopico Alejandro M AM
Nature neuroscience 20051211 1
High-conductance, Ca(2+)-activated and voltage-gated (BK) channels set neuronal firing. They are almost universally activated by alcohol, leading to reduced neuronal excitability and neuropeptide release and to motor intoxication. However, several BK channels are inhibited by alcohol, and most other voltage-gated K(+) channels are refractory to drug action. BK channels are homotetramers (encoded by Slo1) that possess a unique transmembrane segment (S0), leading to a cytosolic S0-S1 loop. We iden ...[more]