Ontology highlight
ABSTRACT:
SUBMITTER: Swendeman S
PROVIDER: S-EPMC2574836 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Swendeman Steven S Mendelson Karen K Weskamp Gisela G Horiuchi Keisuke K Deutsch Urban U Scherle Peggy P Hooper Andrea A Rafii Shahin S Blobel Carl P CP
Circulation research 20080925 9
Vascular endothelial growth factor (VEGF)-A and the VEGF receptors are critical for regulating angiogenesis during development and homeostasis and in pathological conditions, such as cancer and proliferative retinopathies. Most effects of VEGF-A are mediated by the VEGFR2 and its coreceptor, neuropilin (NRP)-1. Here, we show that VEGFR2 is shed from cells by the metalloprotease disintegrin ADAM17, whereas NRP-1 is released by ADAM10. VEGF-A enhances VEGFR2 shedding by ADAM17 but not shedding of ...[more]