Ontology highlight
ABSTRACT:
SUBMITTER: Maynard S
PROVIDER: S-EPMC2574957 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Maynard Scott S Swistowska Anna Maria AM Lee Jae Wan JW Liu Ying Y Liu Su-Ting ST Da Cruz Alexandre Bettencourt AB Rao Mahendra M de Souza-Pinto Nadja C NC Zeng Xianmin X Bohr Vilhelm A VA
Stem cells (Dayton, Ohio) 20080619 9
Embryonic stem cells need to maintain genomic integrity so that they can retain the ability to differentiate into multiple cell types without propagating DNA errors. Previous studies have suggested that mechanisms of genome surveillance, including DNA repair, are superior in mouse embryonic stem cells compared with various differentiated murine cells. Using single-cell gel electrophoresis (comet assay) we found that human embryonic stem cells (BG01, I6) have more efficient repair of different ty ...[more]