Ontology highlight
ABSTRACT:
SUBMITTER: Jang J
PROVIDER: S-EPMC5549766 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Jang Jiho J Huh Yong Jun YJ Cho Hyun-Ju HJ Lee Boram B Park Jaepil J Hwang Dong-Youn DY Kim Dong-Wook DW
Stem cell reports 20170706 2
Human embryonic stem cells (hESCs) hold great promise for the treatment of many incurable diseases. Sirtuin1 (SIRT1), a class III histone deacetylase, is abundantly expressed in hESCs and is known to regulate early differentiation and telomere elongation. Here, we show that downregulation of SIRT1 promotes cell death in hESCs, but not in differentiated cells, and the SIRT1-inhibition-mediated cell death is preceded by increased DNA damage. This increased DNA damage is at least partially due to d ...[more]