Ontology highlight
ABSTRACT:
SUBMITTER: Tcherpakov M
PROVIDER: S-EPMC2575167 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Tcherpakov Marianna M Broday Limor L Delaunay Agnes A Kadoya Takayuki T Khurana Ashwani A Erdjument-Bromage Hediye H Tempst Paul P Qiu Xiao-Bo XB DeMartino George N GN Ronai Ze'ev Z
Molecular biology of the cell 20080910 11
Clearance of misfolded proteins from the ER is central for maintenance of cellular homeostasis. This process requires coordinated recognition, ER-cytosol translocation, and finally ubiquitination-dependent proteasomal degradation. Here, we identify an ER resident seven-transmembrane protein (JAMP) that links ER chaperones, channel proteins, ubiquitin ligases, and 26S proteasome subunits, thereby optimizing degradation of misfolded proteins. Elevated JAMP expression promotes localization of prote ...[more]