Ontology highlight
ABSTRACT:
SUBMITTER: Chen CY
PROVIDER: S-EPMC4283407 | biostudies-other | 2014 Nov
REPOSITORIES: biostudies-other
Chen Chia-yi CY Malchus Nicole S NS Hehn Beate B Stelzer Walter W Avci Dönem D Langosch Dieter D Lemberg Marius K MK
The EMBO journal 20140919 21
Signal peptide peptidase (SPP) catalyzes intramembrane proteolysis of signal peptides at the endoplasmic reticulum (ER), but has also been suggested to play a role in ER-associated degradation (ERAD). Here, we show that SPP forms a complex with the ERAD factor Derlin1 and the E3 ubiquitin ligase TRC8 to cleave the unfolded protein response (UPR) regulator XBP1u. Cleavage occurs within a so far unrecognized type II transmembrane domain, which renders XBP1u as an SPP substrate through specific seq ...[more]