Ontology highlight
ABSTRACT:
SUBMITTER: Kawamata N
PROVIDER: S-EPMC2575257 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Kawamata Norihiko N Ogawa Seishi S Zimmermann Martin M Niebuhr Birte B Stocking Carol C Sanada Masashi M Hemminki Kari K Yamatomo Go G Nannya Yasuhito Y Koehler Rolf R Flohr Thomas T Miller Carl W CW Harbott Jochen J Ludwig Wolf-Dieter WD Stanulla Martin M Schrappe Martin M Bartram Claus R CR Koeffler H Phillip HP
Proceedings of the National Academy of Sciences of the United States of America 20080812 33
High-resolution single nucleotide polymorphism genomic microarray (SNP-chip) is a useful tool to define gene dosage levels over the whole genome, allowing precise detection of deletions and duplications/amplifications of chromosomes in cancer cells. We found that this new technology can also identify breakpoints of chromosomes involved in unbalanced translocations, leading to identification of fusion genes. Using this technique, we found that the PAX5 gene was rearranged to a variety of partner ...[more]