Molecular characterization of a variant of Bacillus anthracis-specific phage AP50 with improved bacteriolytic activity.
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ABSTRACT:
SUBMITTER: Sozhamannan S
PROVIDER: S-EPMC2576697 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
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Molecular characterization of a variant of Bacillus anthracis-specific phage AP50 with improved bacteriolytic activity.
Sozhamannan Shanmuga S McKinstry Michael M Lentz Shannon M SM Jalasvuori Matti M McAfee Farrell F Smith Angela A Dabbs Jason J Ackermann Hans-W HW Bamford Jaana K H JK Mateczun Alfred A Read Timothy D TD
Applied and environmental microbiology 20080912 21
The genome sequence of a Bacillus anthracis-specific clear plaque mutant phage, AP50c, contains 31 open reading frames spanning 14,398 bp, has two mutations compared to wild-type AP50t, and has a colinear genome architecture highly similar to that of gram-positive Tectiviridae phages. Spontaneous AP50c-resistant B. anthracis mutants exhibit a mucoid colony phenotype. ...[more]
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