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Molecular characterization of a variant of Bacillus anthracis-specific phage AP50 with improved bacteriolytic activity.

ABSTRACT: The genome sequence of a Bacillus anthracis-specific clear plaque mutant phage, AP50c, contains 31 open reading frames spanning 14,398 bp, has two mutations compared to wild-type AP50t, and has a colinear genome architecture highly similar to that of gram-positive Tectiviridae phages. Spontaneous AP50c-resistant B. anthracis mutants exhibit a mucoid colony phenotype.

SUBMITTER: Sozhamannan S 

PROVIDER: S-EPMC2576697 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Molecular characterization of a variant of Bacillus anthracis-specific phage AP50 with improved bacteriolytic activity.

Sozhamannan Shanmuga S   McKinstry Michael M   Lentz Shannon M SM   Jalasvuori Matti M   McAfee Farrell F   Smith Angela A   Dabbs Jason J   Ackermann Hans-W HW   Bamford Jaana K H JK   Mateczun Alfred A   Read Timothy D TD  

Applied and environmental microbiology 20080912 21

The genome sequence of a Bacillus anthracis-specific clear plaque mutant phage, AP50c, contains 31 open reading frames spanning 14,398 bp, has two mutations compared to wild-type AP50t, and has a colinear genome architecture highly similar to that of gram-positive Tectiviridae phages. Spontaneous AP50c-resistant B. anthracis mutants exhibit a mucoid colony phenotype. ...[more]

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