PlyPH, a bacteriolytic enzyme with a broad pH range of activity and lytic action against Bacillus anthracis.
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ABSTRACT:
SUBMITTER: Yoong P
PROVIDER: S-EPMC1428399 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Publications
PlyPH, a bacteriolytic enzyme with a broad pH range of activity and lytic action against Bacillus anthracis.
Yoong Pauline P Schuch Raymond R Nelson Daniel D Fischetti Vincent A VA
Journal of bacteriology 20060401 7
We have cloned a lytic enzyme, PlyPH, with a specific lytic effect on Bacillus anthracis strains. PlyPH remains active between pH 4 and 10.5, and a single dose rescued a significant percentage of mice infected intraperitoneally with an attenuated B. anthracis strain. We propose PlyPH as a novel therapeutic agent. ...[more]
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