Dataset Information

Green tea (Camellia sinensis) and cancer prevention: a systematic review of randomized trials and epidemiological studies.

ABSTRACT:

Background

Green tea is one of the most popular beverages worldwide. This review summarizes the beneficial effects of green tea on cancer prevention.

Methods

Electronic databases, including PubMed (1966-2008), the Cochrane Library (Issue 1, 2008) and Chinese Biomedical Database (1978-2008) with supplement of relevant websites, were searched. There was no language restriction. The searches ended at March 2008. We included randomized and non-randomized clinical trials, epidemiological studies (cohort and case-control) and a meta-analysis. We excluded case series, case reports, in vitro and animal studies. Outcomes were measured with estimation of relative risk, hazard or odd ratios, with 95% confidence interval.

Results

Forty-three epidemiological studies, four randomized trials and one meta-analysis were identified. The overall quality of these studies was evaluated as good or moderate. While some evidence suggests that green tea has beneficial effects on gastrointestinal cancers, the findings are not consistent.

Conclusion

Green tea may have beneficial effects on cancer prevention. Further studies such as large and long term cohort studies and clinical trials are warranted.

SUBMITTER: Liu J

PROVIDER: S-EPMC2577676 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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Publications

Green tea (Camellia sinensis) and cancer prevention: a systematic review of randomized trials and epidemiological studies.

Liu Jianping J Xing Jianmin J Fei Yutong Y

Chinese medicine 20081022

<h4>Background</h4>Green tea is one of the most popular beverages worldwide. This review summarizes the beneficial effects of green tea on cancer prevention.<h4>Methods</h4>Electronic databases, including PubMed (1966-2008), the Cochrane Library (Issue 1, 2008) and Chinese Biomedical Database (1978-2008) with supplement of relevant websites, were searched. There was no language restriction. The searches ended at March 2008. We included randomized and non-randomized clinical trials, epidemiologic ...[more]

PMID: 18940008

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Project description:Tea green leafhopper [Empoasca (Matsumurasca) onukii Matsuda] is one of the most devastating pests of tea plants (Camellia sinensis), greatly impacting tea yield and quality. A thorough understanding of the interactions between the tea green leafhopper and the tea plant would facilitate a better pest management. To gain more insights into the molecular and biochemical mechanisms behind their interactions, a combined analysis of the global transcriptome and metabolome reconfiguration of the tea plant challenged with tea green leafhoppers was performed for the first time, complemented with phytohormone analysis. Non-targeted metabolomics analysis by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF MS), together with quantifications by ultra-performance liquid chromatography triple quadrupole mass spectrometry (UPLC-QqQ MS), revealed a marked accumulation of various flavonoid compounds and glycosidically bound volatiles but a great reduction in the level of amino acids and glutathione upon leaf herbivory. RNA-Seq data analysis showed a clear modulation of processes related to plant defense. Genes pertaining to the biosynthesis of phenylpropanoids and flavonoids, plant-pathogen interactions, and the biosynthesis of cuticle wax were significantly up-regulated. In particular, the transcript level for a CER1 homolog involved in cuticular wax alkane formation was most drastically elevated and an increase in C29 alkane levels in tea leaf waxes was observed. The tea green leafhopper attack triggered a significant increase in salicylic acid (SA) and a minor increase in jasmonic acid (JA) in infested tea leaves. Moreover, transcription factors (TFs) constitute a large portion of differentially expressed genes, with several TFs families likely involved in SA and JA signaling being significantly induced by tea green leafhopper feeding. This study presents a valuable resource for uncovering insect-induced genes and metabolites, which can potentially be used to enhance insect resistance in tea plants.

Dataset Information

Green tea (Camellia sinensis) and cancer prevention: a systematic review of randomized trials and epidemiological studies.

Background

Methods

Results

Conclusion

Publications

Green tea (Camellia sinensis) and cancer prevention: a systematic review of randomized trials and epidemiological studies.

Similar Datasets

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