Ontology highlight
ABSTRACT:
SUBMITTER: Boger DL
PROVIDER: S-EPMC25778 | biostudies-literature | 2000 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20000501 10
The development of exceptionally potent inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid), and anandamide (an endogenous ligand for cannabinoid receptors) is detailed. The inhibitors may serve as useful tools to clarify the role of endogenous oleamide and anandamide and may prove to be useful therapeutic agents for the treatment of sleep disorders or pain. The combination of several features-an optimal C12 ...[more]