Ontology highlight
ABSTRACT:
SUBMITTER: Romero FA
PROVIDER: S-EPMC2531193 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20070206 5
A study of the structure-activity relationships (SAR) of 2f (OL-135), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed, targeting the 5-position of the oxazole. Examination of a series of substituted benzene derivatives (12-14) revealed that the optimal position for substitution was the meta-position with selected members approaching or exceeding the potency of 2f. Concurrent with these studies, the effect of substitution on the pyridine ring of 2f was also examined. A series ...[more]