Fragment-HMM: a new approach to protein structure prediction.
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ABSTRACT:
SUBMITTER: Li SC
PROVIDER: S-EPMC2578800 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Fragment-HMM: a new approach to protein structure prediction.
Li Shuai Cheng SC Bu Dongbo D Xu Jinbo J Li Ming M
Protein science : a publication of the Protein Society 20080822 11
We designed a simple position-specific hidden Markov model to predict protein structure. Our new framework naturally repeats itself to converge to a final target, conglomerating fragment assembly, clustering, target selection, refinement, and consensus, all in one process. Our initial implementation of this theory converges to within 6 A of the native structures for 100% of decoys on all six standard benchmark proteins used in ROSETTA (discussed by Simons and colleagues in a recent paper), which ...[more]
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