A physical approach to protein structure prediction.
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ABSTRACT:
SUBMITTER: Crivelli S
PROVIDER: S-EPMC1302447 | biostudies-other | 2002 Jan
REPOSITORIES: biostudies-other
Publications
A physical approach to protein structure prediction.
Crivelli Silvia S Eskow Elizabeth E Bader Brett B Lamberti Vincent V Byrd Richard R Schnabel Robert R Head-Gordon Teresa T
Biophysical journal 20020101 1 Pt 1
We describe our global optimization method called Stochastic Perturbation with Soft Constraints (SPSC), which uses information from known proteins to predict secondary structure, but not in the tertiary structure predictions or in generating the terms of the physics-based energy function. Our approach is also characterized by the use of an all atom energy function that includes a novel hydrophobic solvation function derived from experiments that shows promising ability for energy discrimination ...[more]
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