Ontology highlight
ABSTRACT:
SUBMITTER: Partovian C
PROVIDER: S-EPMC2578831 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Partovian Chohreh C Ju Rong R Zhuang Zhen W ZW Martin Kathleen A KA Simons Michael M
Molecular cell 20081001 1
Mammalian target of rapamycin (mTOR) activity is regulated by assembly of two functionally distinct complexes, mTORC1 and mTORC2. In syndecan-4 (S4) null endothelial cells, mTORC2 activity is reduced, resulting in decreased Akt activation, while mTORC1 activity is increased. Levels of rictor, mLST8, and mSin-1 are unchanged in total cell lysates but decreased in the rafts of S4(-/-) endothelial cells, as is the level of PKCalpha. Expression of myristoylated-PKCalpha in S4(-/-) cells restores ric ...[more]