Ontology highlight
ABSTRACT:
SUBMITTER: Ye J
PROVIDER: S-EPMC25792 | biostudies-literature | 2000 May
REPOSITORIES: biostudies-literature
Ye J J Davé U P UP Grishin N V NV Goldstein J L JL Brown M S MS
Proceedings of the National Academy of Sciences of the United States of America 20000501 10
The NH(2)-terminal domains of membrane-bound sterol regulatory element-binding proteins (SREBPs) are released into the cytosol by regulated intramembrane proteolysis, after which they enter the nucleus to activate genes encoding lipid biosynthetic enzymes. Intramembrane proteolysis is catalyzed by Site-2 protease (S2P), a hydrophobic zinc metalloprotease that cleaves SREBPs at a membrane-embedded leucine-cysteine bond. In the current study, we use domain-swapping methods to localize the residues ...[more]