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Ghrelin receptor gene polymorphisms and body size in children and adults.

ABSTRACT: BACKGROUND:The GH secretagogue receptor type 1a gene (GHSR) encodes the cognate receptor of ghrelin, a gut hormone that regulates food intake and pituitary GH secretion. Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth. AIM:The aim of the study was to test common genetic variation in GHSR for association with body size in children and adults. METHODS:Sequencing was performed to systematically identify novel single nucleotide polymorphisms (SNPs) in GHSR. A set of three haplotype-tagging SNPs that captured all the genetic variation in GHSR was identified. These three haplotype-tagging SNPs were then genotyped in three large population-based U.K. cohort studies (two adult and one childhood cohort) comprising 5807 adults and 843 children. RESULTS:No significant genotype or haplotype associations were found with adult or childhood height, weight, or body mass index. CONCLUSION:Common variation in GHSR is not associated with body size in U.K. adults or children.

SUBMITTER: Garcia EA

PROVIDER: S-EPMC2579991 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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Ghrelin receptor gene polymorphisms and body size in children and adults.

Garcia Edwin A EA Heude Barbara B Petry Clive J CJ Gueorguiev Maria M Hassan-Smith Zaki K ZK Spanou Antigoni A Ring Susan M SM Dunger David B DB Wareham Nicholas N Sandhu Manjinder S MS Ong Ken K KK Korbonits Márta M

The Journal of clinical endocrinology and metabolism 20080722 10

<h4>Background</h4>The GH secretagogue receptor type 1a gene (GHSR) encodes the cognate receptor of ghrelin, a gut hormone that regulates food intake and pituitary GH secretion. Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth.<h4>Aim</h4>The aim of the study was to test common genetic variation in GHSR for association with body size in children and adults.<h4>Methods</h4>Sequencing was per ...[more]

PMID: 18647811

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Project description:BACKGROUND:Dopamine is involved in several cerebral physiological processes, and single nucleotide polymorphisms (SNP) in the dopamine D2 receptor gene (DRD2) have been associated with numerous neurological and mental disorders, including those involving alterations in cognitive and emotional processes. METHODS:The aim of this study was to evaluate the association between the SNPs c.957C > T (rs6277) and c.-585A > G (rs1799978) in the DRD2 gene and behavioral characteristics of children and adolescents based on an inventory of the Child Behavior Checklist (CBCL). Children and adolescents between 8 and 20 years old who were clinically followed-up were genotyped for the SNPs c.957C > T and c.-585A > G, and related to data of the CBCL/6-18 scale assessment performed with the help of caregivers. The chi-squared test was used to assess the differences in the frequencies of the C and T alleles in the polymorphism c.957C > T and of the A and G alleles in the polymorphism c.-585A > G with respect to the grouped CBCL scores at a significance level of 5%. Multiple logistic regression models were performed, to control whether sex and/or ethnicity could influence the results. RESULTS:Eighty-five patients were assessed overall, and the presence of the T allele (C/T and T/T) of DRD2 c.957C > T polymorphism was found to be significantly associated with the occurrence of defiant and oppositional problems and with attention and hyperactivity problems. There were no associations detected with polymorphism DRD2 c.-585A > G polymorphism. Both SNPs were in Hardy-Weinberg-equilibrium. CONCLUSIONS:Although the findings of this study are preliminary, due to its small number of participants, the presence of T allele (C/T, T/T) in c.957C > T SNP was associated with difficulty in impulse control, self-control of emotions, and conduct adjustment, which can contribute to improving the identification of mental and behavioral phenotypes associated with gene expression.

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Ghrelin receptor gene polymorphisms and body size in children and adults.

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Ghrelin receptor gene polymorphisms and body size in children and adults.

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