Dp71, utrophin and beta-dystroglycan expression and distribution in PC12/L6 cell cocultures.
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ABSTRACT:
SUBMITTER: Ilarraza-Lomeli R
PROVIDER: S-EPMC2580073 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Publications
Dp71, utrophin and beta-dystroglycan expression and distribution in PC12/L6 cell cocultures.
Ilarraza-Lomeli Ramses R Cisneros-Vega Bulmaro B Cervantes-Gomez Maria de Lourdes Mde L Mornet Dominique D Montañez Cecilia C
Neuroreport 20071001 16
Function of dystrophin Dp71 isoforms is unknown but seems related to neurite outgrowth and synapse formation. To evaluate Dp71 role in myoneural synapses, we established a coculture model using PC12 cells and L6 myotubes and analyzed expression and localization of Dp71 and related proteins, utrophin and beta-dystroglycan, in PC12 cells. Confocal microscopy showed Dp71d isoform in PC12 nuclei, golgi-complex-like and endoplasmic reticulum-like structures, whereas Dp71ab concentrates at neurite tip ...[more]
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