Ontology highlight
ABSTRACT:
SUBMITTER: Petrova K
PROVIDER: S-EPMC2580781 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Petrova Kseniya K Oyadomari Seiichi S Hendershot Linda M LM Ron David D
The EMBO journal 20081016 21
P58/DNAJc3 defends cells against endoplasmic reticulum (ER) stress. Most P58 molecules are translocated into the ER lumen, and here we report selective and stable binding to misfolded proteins by P58's TPR-containing N-terminal domain. In vitro, too, P58 binds selectively to a model misfolded protein and challenge of that complex with physiological concentrations of the ER lumenal Hsp70-type chaperone BiP encourages disassembly. BiP-induced dissociation of P58 from its substrate depends on the p ...[more]