Ontology highlight
ABSTRACT:
SUBMITTER: Ambrosio AL
PROVIDER: S-EPMC2581521 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Ambrosio Andrea L AL Taelman Vincent F VF Lee Hojoon X HX Metzinger Carrie A CA Coffinier Catherine C De Robertis E M EM
Developmental cell 20080801 2
Vertebrate Crossveinless-2 (CV2) is a secreted protein that can potentiate or antagonize BMP signaling. Through embryological and biochemical experiments we find that: (1) CV2 functions as a BMP4 feedback inhibitor in ventral regions of the Xenopus embryo; (2) CV2 complexes with Twisted gastrulation and BMP4; (3) CV2 is not a substrate for tolloid proteinases; (4) CV2 binds to purified Chordin protein with high affinity (K(D) in the 1 nM range); (5) CV2 binds even more strongly to Chordin proteo ...[more]