Ontology highlight
ABSTRACT:
SUBMITTER: Hausmann S
PROVIDER: S-EPMC2581544 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Hausmann Stéphane S Zheng Sushuang S Costanzo Michael M Brost Renee L RL Garcin Dominique D Boone Charles C Shuman Stewart S Schwer Beate B
The Journal of biological chemistry 20080905 46
Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m(7)G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal small nuclear RNAs. Fungi and mammalian somatic cells are able to grow in the absence of Tgs1 and TMG caps, suggesting that an essential function of the TMG cap might be obscured by functional redundancy. A systematic screen in budding yeast identified nonessential genes that, when deleted, caused synthetic growth defects with tgs1Delta. The ...[more]